The HLA complex genes help the body's immune system differentiate between the body's proteins from those made by viruses and bacteria. Studies show that the most common genes associated with Addison's disease belong to the human leukocyte antigen or HLA complex. Few treatments required for Cushing's syndrome (characterized by very high levels of cortisol)īesides familial history, researchers also indicate that a few genes may increase an individual's risk for Addison's disease.A build-up of amyloid protein in the adrenal gland.Heavy bleeding in the adrenal gland (hemorrhage).Tuberculosis (the most common cause of Addison's disease globally).It is still unclear why people develop this autoimmune disorder, but researchers speculate this disease may run in families. When over 90% of the adrenal cortex is damaged, the gland cannot produce sufficient hormones, resulting in Addison's disease. Image: Is Addison’s Disease Genetic? Common Symptoms Causes of Addison's DiseaseĪddison's disease occurs when immune system cells attack and damage the outer part of the adrenal gland (called the cortex).
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